Dataset Information

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people.

ABSTRACT:

Objectives

Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the association of chronic HBV infection with total and cause-specific mortality.

Design

Population-based prospective cohort study.

Setting

China Kadoorie Biobank in which participants from 10 geographically diverse areas across China were enrolled between 2004 and 2008.

Participants

475?801 participants 30-79 years of age without reporting major chronic diseases at baseline were enrolled. Hepatitis B surface antigen (HBsAg) was tested using an on-site rapid test strip at baseline.

Primary and secondary outcome measures

Total and cause-specific mortality.

Results

A total of 35?822 deaths were recorded during ~10 years of follow-up. In multivariable-adjusted analyses, compared with HBsAg-negative participants, HBsAg-positive participants had an increased risk of total mortality (HR=2.01, 95% CI: 1.91 to 2.12), which was higher in men (HR=2.16, 95%?CI: 2.01 to 2.31) than in women (HR=1.74, 95%?CI: 1.60 to 1.90). Presence of HBsAg was associated with increased mortality from liver cancer (1339 deaths, HR=13.95, 95%?CI: 12.46 to 15.62), infections (410 deaths, HR=10.30, 95%?CI: 8.21 to 12.94), digestive diseases (688 deaths, HR=6.83, 95%?CI: 5.49 to 8.50), intracerebral haemorrhage (4077 deaths, HR=1.38, 95%?CI: 1.14 to 1.68) and ischaemic heart diseases (4624 deaths, HR=1.31, 95%?CI: 1.09 to 1.58). The positive association between HBsAg status and risk of death was stronger in participants younger than 50 years, smokers, physically active or non-hypertensive participants.

Conclusions

Among Chinese adults, chronic HBV infection was associated with increased mortality from a range of hepatic and extrahepatic diseases.

SUBMITTER: Si J

PROVIDER: S-EPMC6500223 | biostudies-literature | 2019 Apr

REPOSITORIES: biostudies-literature

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Publications

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people.

Si Jiahui J Yu Canqing C Guo Yu Y Bian Zheng Z Meng Ruogu R Yang Ling L Chen Yiping Y Jin Jianrong J Liu Jingchao J Guo Ziyan Z Chen Junshi J Chen Zhengming Z Lv Jun J Li Liming L

BMJ open 20190409 4

<h4>Objectives</h4>Chronic hepatitis B virus (HBV) infection is associated with a higher risk of liver diseases. Substantial uncertainty remains, however, about the associations of HBV infection with mortality from extrahepatic causes, especially from subtypes of cardiovascular diseases. We prospectively examined the association of chronic HBV infection with total and cause-specific mortality.<h4>Design</h4>Population-based prospective cohort study.<h4>Setting</h4>China Kadoorie Biobank in which ...[more]

PMID: 30967410

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Dataset Information

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people.

Objectives

Design

Setting

Participants

Primary and secondary outcome measures

Results

Conclusions

Publications

Chronic hepatitis B virus infection and total and cause-specific mortality: a prospective cohort study of 0.5 million people.

Similar Datasets

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