Ontology highlight
ABSTRACT:
SUBMITTER: Mohanty S
PROVIDER: S-EPMC6367456 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Mohanty Suchismita S Yerneni Ketan K Theruvath Johanna Lena JL Graef Claus Moritz CM Nejadnik Hossein H Lenkov Olga O Pisani Laura L Rosenberg Jarrett J Mitra Siddhartha S Cordero Alejandro Sweet AS Cheshier Samuel S Daldrup-Link Heike E HE
Cell death & disease 20190115 2
CD47 monoclonal antibodies (mAbs) activate tumor-associated macrophages (TAMs) in sarcomas to phagocytose and eliminate cancer cells. Though CD47 mAbs have entered clinical trials, diagnostic tests for monitoring therapy response in vivo are currently lacking. Ferumoxytol is an FDA-approved iron supplement which can be used "off label" as a contrast agent: the nanoparticle-based drug is phagocytosed by TAM and can be detected with magnetic resonance imaging (MRI). We evaluated if ferumoxytol-enh ...[more]