Longitudinal decreases in suicidal ideation are associated with increases in salience network coherence in depressed adolescents.

ABSTRACT:

Background

Suicidal ideation (SI) is an important predictor of suicide attempt, yet SI is difficult to predict. Given that SI begins in adolescence when brain networks are maturing, it is important to understand associations between network functioning and changes in severity of SI.

Methods

Thirty-three depressed adolescents were administered the Columbia-Suicide Severity Rating Scale to assess SI and completed resting-state fMRI at baseline (T1) and 6 months later (T2). We computed coherence in the executive control (ECN), default mode (DMN), salience (SN), and non-relevant noise networks and then examined the association between changes in brain network coherence and changes in SI severity from T1 to T2.

Results

A greater reduction in severity of SI was associated w

SUBMITTER: Schwartz J 

PROVIDER: S-EPMC6367710 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature