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Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation.


ABSTRACT:

Background

The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT).

Methods

Peripheral blood samples were collected for measuring monocytic (M-) MDSCs (CD14posHLA-DRlow/neg) and early-stage (E-) MDSCs (LinnegHLA-DRnegCD33posCD11bpos) before and after ASCT. Clinical outcomes following ASCT differed according to the frequency of each MDSC phenotype.

Results

In the pre-ASCT analyses, lower M-MDSCs (ConclusionsOur data demonstrate that pre-ASCT M-MDSCs are correlated with poor clinical outcomes after ASCT through reduced cytotoxicity of melphalan. We propose that targeting CSF1R on these cells may improve the results of ASCT in MM.

SUBMITTER: Lee SE 

PROVIDER: S-EPMC6367772 | biostudies-literature | 2019 Feb

REPOSITORIES: biostudies-literature

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Publications

Different role of circulating myeloid-derived suppressor cells in patients with multiple myeloma undergoing autologous stem cell transplantation.

Lee Sung-Eun SE   Lim Ji-Young JY   Kim Tae Woo TW   Ryu Da-Bin DB   Park Sung Soo SS   Jeon Young-Woo YW   Yoon Jae-Ho JH   Cho Byung-Sik BS   Eom Ki-Seong KS   Kim Yoo-Jin YJ   Kim Hee-Je HJ   Lee Seok S   Cho Seok-Goo SG   Kim Dong-Wook DW   Lee Jong Wook JW   Min Chang-Ki CK  

Journal for immunotherapy of cancer 20190207 1


<h4>Background</h4>The aim of this study is to evaluate the prognostic impact of myeloid-derived suppressor cells (MDSCs) in multiple myeloma (MM) in the context of autologous stem cell transplantation (ASCT).<h4>Methods</h4>Peripheral blood samples were collected for measuring monocytic (M-) MDSCs (CD14<sup>pos</sup>HLA-DR<sup>low/neg</sup>) and early-stage (E-) MDSCs (Lin<sup>neg</sup>HLA-DR<sup>neg</sup>CD33<sup>pos</sup>CD11b<sup>pos</sup>) before and after ASCT. Clinical outcomes following  ...[more]

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