Ontology highlight
ABSTRACT:
SUBMITTER: Fan C
PROVIDER: S-EPMC6368340 | biostudies-literature | 2018 Jul
REPOSITORIES: biostudies-literature
Fan Chao C Fan Minrui M Orlando Benjamin J BJ Fastman Nathan M NM Zhang Jinru J Xu Yan Y Chambers Melissa G MG Xu Xiaofang X Perry Kay K Liao Maofu M Feng Liang L
Nature 20180711 7715
Mitochondrial calcium uptake is critical for regulating ATP production, intracellular calcium signalling, and cell death. This uptake is mediated by a highly selective calcium channel called the mitochondrial calcium uniporter (MCU). Here, we determined the structures of the pore-forming MCU proteins from two fungi by X-ray crystallography and single-particle cryo-electron microscopy. The stoichiometry, overall architecture, and individual subunit structure differed markedly from those described ...[more]