Ontology highlight
ABSTRACT:
SUBMITTER: Yoo J
PROVIDER: S-EPMC6155975 | biostudies-literature | 2018 Aug
REPOSITORIES: biostudies-literature
Science (New York, N.Y.) 20180628 6401
Calcium transport plays an important role in regulating mitochondrial physiology and pathophysiology. The mitochondrial calcium uniporter (MCU) is a calcium-selective ion channel that is the primary mediator for calcium uptake into the mitochondrial matrix. Here, we present the cryo-electron microscopy structure of the full-length MCU from <i>Neurospora crassa</i> to an overall resolution of ~3.7 angstroms. Our structure reveals a tetrameric architecture, with the soluble and transmembrane domai ...[more]