Ontology highlight
ABSTRACT:
SUBMITTER: Betts BC
PROVIDER: S-EPMC6368389 | biostudies-literature | 2017 Jan
REPOSITORIES: biostudies-literature
Betts Brian C BC Veerapathran Anandharaman A Pidala Joseph J Yang Hua H Horna Pedro P Walton Kelly K Cubitt Christopher L CL Gunawan Steven S Lawrence Harshani R HR Lawrence Nicholas J NJ Sebti Said M SM Anasetti Claudio C
Science translational medicine 20170101 372
Graft-versus-host disease (GVHD) is a leading cause of nonrelapse mortality after allogeneic hematopoietic cell transplantation. T cell costimulation by CD28 contributes to GVHD, but prevention is incomplete when targeting CD28, downstream mammalian target of rapamycin (mTOR), or Aurora A. Likewise, interleukin-6 (IL-6)-mediated Janus kinase 2 (JAK2) signaling promotes alloreactivity, yet JAK2 inhibition does not eliminate GVHD. We provide evidence that blocking Aurora A and JAK2 in human T cell ...[more]