Ontology highlight
ABSTRACT:
SUBMITTER: Burnell ES
PROVIDER: S-EPMC6368479 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Burnell Erica S ES Irvine Mark M Fang Guangyu G Sapkota Kiran K Jane David E DE Monaghan Daniel T DT
Journal of medicinal chemistry 20180305 1
Excitatory activity in the CNS is predominately mediated by l-glutamate through several families of l-glutamate neurotransmitter receptors. Of these, the N-methyl-d-aspartate receptor (NMDAR) family has many critical roles in CNS function and in various neuropathological and psychiatric conditions. Until recently, the types of compounds available to regulate NMDAR function have been quite limited in terms of mechanism of action, subtype selectivity, and biological effect. However, several new cl ...[more]