Ontology highlight
ABSTRACT:
SUBMITTER: Romo CG
PROVIDER: S-EPMC6368694 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Romo Carlos G CG Palsgrove Doreen N DN Sivakumar Ananyaa A Elledge Christen R CR Kleinberg Lawrence R LR Chaichana Kaisorn L KL Gocke Christopher D CD Rodriguez Fausto J FJ Holdhoff Matthias M
Diagnostic pathology 20190209 1
<h4>Background</h4>Gliomas with 1p/19q-codeletion as well as mutation of isocitrate dehydrogenase (IDH) 1 are typically characterized as oligodendrogliomas with comparatively good response to treatment with radiation and chemotherapy.<h4>Case presentation</h4>We present the case of a 28-year-old man with an IDH1 and TP53 mutant high grade glioma with abnormalities in chromosomes 1 and 19 suggestive of anaplastic oligodendroglioma that rapidly progressed to widespread metastatic disease. Biopsy o ...[more]