Ontology highlight
ABSTRACT:
SUBMITTER: Bhatia S
PROVIDER: S-EPMC6368904 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Bhatia Shailender S Miller Natalie J NJ Lu Hailing H Longino Natalie V NV Ibrani Dafina D Shinohara Michi M MM Byrd David R DR Parvathaneni Upendra U Kulikauskas Rima R Ter Meulen Jan J Hsu Frank J FJ Koelle David M DM Nghiem Paul P
Clinical cancer research : an official journal of the American Association for Cancer Research 20180809 4
<h4>Purpose</h4>G100 is a toll-like receptor 4 (TLR4) agonist that triggers innate and adaptive antitumor immune responses in preclinical models. This pilot study assessed the safety, efficacy, and immunologic activity of intratumoral (IT) administration of G100 in patients with Merkel cell carcinoma (MCC).<h4>Patients and methods</h4>Patients with locoregional MCC (<i>n</i> = 3; cohort A) received neoadjuvant IT G100 (2 weekly doses at 5 μg/dose) followed by surgery and radiotherapy; patients w ...[more]