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ABSTRACT:
SUBMITTER: Ashok P
PROVIDER: S-EPMC6369240 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Ashok Penta P Chander Subhash S Smith Terry K TK Prakash Singh Rajnish R Jha Prabhat Nath PN Sankaranarayanan Murugesan M
Bioorganic chemistry 20181122
A series of piperazinyl-β-carboline-3-carboxamide derivatives were designed through a molecular hybridization approach. Designed analogues were synthesized, characterized and evaluated for anti-leishmanial activity against Leishmania infantum and Leishmania donovani. In L. infantum inhibition assay, compounds 7d, 7g and 7c displayed potent inhibition of promastigotes (EC<sub>50</sub> 1.59, 1.47 and 3.73 µM respectively) and amastigotes (EC<sub>50</sub> 1.4, 1.9 and 2.6 µM respectively). SAR stud ...[more]