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Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives.

ABSTRACT: We have synthesized new series of bisindole analogs (1-27), characterized by ¹HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC₅₀ values ranging from 0.7?±?0.01 to 13.30?±?0.50 µM respectively when compared with standard pentamidine with IC₅₀ value of 7.20?±?0.20 µM. All analogs showed greater potential than standard except 10, 19 and 23 when compared with standard. Structure activity relationship has been also established for all compounds. Molecular docking studies were carried out to understand the binding interaction of active molecules.

SUBMITTER: Taha M

PROVIDER: S-EPMC6685257 | biostudies-literature | 2019 Dec

REPOSITORIES: biostudies-literature

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Synthesis, anti-leishmanial and molecular docking study of bis-indole derivatives.

Taha Muhammad M Uddin Imad I Gollapalli Mohammed M Almandil Noor Barak NB Rahim Fazal F Farooq Rai Khalid RK Nawaz Muhammad M Ibrahim Mohamed M Alqahtani Mohammed A MA Bamarouf Yasser A YA Selvaraj Manikandan M

BMC chemistry 20190806 1

We have synthesized new series of bisindole analogs (1-27), characterized by 1HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC50 values ranging from 0.7 ± 0.01 to 13.30 ± 0.50 µM respectively when compared with standard pentamidine with IC50 value of 7.20 ± 0.20 µM. All analogs showed greater potential than standard except 10, 19 and 23 when compa ...[more]

PMID: 31410413

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