Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI.
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ABSTRACT:
SUBMITTER: De Santis S
PROVIDER: S-EPMC6370560 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Evidence of early microstructural white matter abnormalities in multiple sclerosis from multi-shell diffusion MRI.
De Santis Silvia S Granberg Tobias T Ouellette Russell R Treaba Constantina A CA Herranz Elena E Fan Qiuyun Q Mainero Caterina C Toschi Nicola N
NeuroImage. Clinical 20190130
Irreversible white matter (WM) damage, including severe demyelination and axonal loss, is a main determinant of long-term disability in multiple sclerosis (MS). Non-invasive detection of changes in microstructural WM integrity in the disease is challenging since commonly used imaging metrics lack the necessary sensitivity, especially in the early phase of the disease. This study aims at assessing microstructural WM abnormalities in early-stage MS by using ultra-high gradient strength multi-shell ...[more]
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