White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study.
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ABSTRACT:
SUBMITTER: Cetin-Karayumak S
PROVIDER: S-EPMC7147982 | biostudies-literature | 2020 Dec
REPOSITORIES: biostudies-literature
Publications
White matter abnormalities across the lifespan of schizophrenia: a harmonized multi-site diffusion MRI study.
Cetin-Karayumak Suheyla S Di Biase Maria A MA Chunga Natalia N Reid Benjamin B Somes Nathaniel N Lyall Amanda E AE Kelly Sinead S Solgun Bengisu B Pasternak Ofer O Vangel Mark M Pearlson Godfrey G Tamminga Carol C Sweeney John A JA Clementz Brett B Schretlen David D Viher Petra Verena PV Stegmayer Katharina K Walther Sebastian S Lee Jungsun J Crow Tim T James Anthony A Voineskos Aristotle A Buchanan Robert W RW Szeszko Philip R PR Malhotra Anil K AK Hegde Rachal R McCarley Robert R Keshavan Matcheri M Shenton Martha M Rathi Yogesh Y Kubicki Marek M
Molecular psychiatry 20190911 12
Several prominent theories of schizophrenia suggest that structural white matter pathologies may follow a developmental, maturational, and/or degenerative process. However, a lack of lifespan studies has precluded verification of these theories. Here, we analyze the largest sample of carefully harmonized diffusion MRI data to comprehensively characterize age-related white matter trajectories, as measured by fractional anisotropy (FA), across the course of schizophrenia. Our analysis comprises di ...[more]
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