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ABSTRACT: Background
We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study.Methods
The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012-2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n?=?97), exercise plus diet (n?=?98) or control group (n?=?48). Both intervention groups aimed for equivalent weight loss (6-7%) following a calorie-restricted diet (diet group) or a partly supervised intensive exercise programme (4?h per week) combined with a small caloric restriction (exercise plus diet group). Outcomes after 16?weeks are amount and distribution of abdominal fat, measured by magnetic resonance imaging (MRI) with the use of the three-point IDEAL Dixon method.Results
The diet and exercise plus diet group lost 6.1 and 6.9% body weight, respectively. Compared to controls, subcutaneous and intra-abdominal fat reduced significantly with both diet (-?12.5% and?-?12.0%) and exercise plus diet (-?16.0% and?-?14.6%). Direct comparison between both interventions revealed that the reduction in subcutaneous fat was statistically significantly larger in the group that combined exercise with diet: an additional 10.6?cm2 (95%CI -18.7; -?2.4) was lost compared to the diet-only group. Intra-abdominal fat loss was not significantly larger in the exercise plus diet group (-?3.8?cm2, 95%CI -9.0; 1.3).Conclusions
We conclude that weight loss of 6-7% with diet or with exercise plus diet reduced both subcutaneous and intra-abdominal fat. Only subcutaneous fat statistically significantly reduced to a larger extent when exercise is combined with a small caloric restriction.Trial register
NCT01511276 (clinicaltrials.gov), prospectively registered.
SUBMITTER: van Gemert WA
PROVIDER: S-EPMC6371569 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
van Gemert Willemijn A WA Peeters Petra H PH May Anne M AM Doornbos Adriaan J H AJH Elias Sjoerd G SG van der Palen Job J Veldhuis Wouter W Stapper Maaike M Schuit Jantine A JA Monninkhof Evelyn M EM
BMC public health 20190211 1
<h4>Background</h4>We assessed the effect of equivalent weight loss with or without exercise on (intra-) abdominal fat in postmenopausal women in the SHAPE-2 study.<h4>Methods</h4>The SHAPE-2 study is a three-armed randomised controlled trial conducted in 2012-2013 in the Netherlands. Postmenopausal overweight women were randomized to a diet (n = 97), exercise plus diet (n = 98) or control group (n = 48). Both intervention groups aimed for equivalent weight loss (6-7%) following a calorie-restri ...[more]