Ontology highlight
ABSTRACT:
SUBMITTER: Clay-Gilmour AI
PROVIDER: S-EPMC6371786 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Clay-Gilmour Alyssa I AI Kumar Shaji S Rajkumar S Vincent SV Rishi Abdul A Kyle Robert A RA Katzmann Jerry A JA Murray David L DL Norman Aaron D AD Greenberg Alexandra J AJ Larson Dirk R DR O'Byrne Megan M MM Slager Susan L SL Vachon Celine M CM
Leukemia 20180910 2
We and others have shown increased risk of monoclonal gammopathy of undetermined significance (MGUS) in first-degree relatives of patients with multiple myeloma (MM). Whether familial risk of MGUS differs by the MM proband's age at onset, tumor or clinical characteristics is unknown. MM and smoldering MM (SMM) cases (N = 430) were recruited from the Mayo Clinic in Rochester, Minnesota between 2005-2015. First-degree relatives over age 40 provided serum samples for evaluation of MGUS (N = 1179). ...[more]