Ontology highlight
ABSTRACT:
SUBMITTER: Lee S
PROVIDER: S-EPMC6371790 | biostudies-literature | 2018 Nov
REPOSITORIES: biostudies-literature
Lee SungKyoung S Cieply Benjamin B Yang Yueqin Y Peart Natoya N Glaser Carl C Chan Patricia P Carstens Russ P RP
Cell reports 20181101 9
The epithelial-specific splicing regulators Esrp1 and Esrp2 are required for mammalian development, including establishment of epidermal barrier functions. However, the mechanisms by which Esrp ablation causes defects in epithelial barriers remain undefined. We determined that the ablation of Esrp1 and Esrp2 impairs epithelial tight junction (TJ) integrity through loss of the epithelial isoform of Rho GTP exchange factor Arhgef11. Arhgef11 is required for the maintenance of TJs via RhoA activati ...[more]