Measured maternal prepregnancy anthropometry and newborn DNA methylation.
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ABSTRACT: Aim
We examined maternal prepregnancy anthropometry and cord blood DNA methylation.Methods
Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.Results
Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni significant CpG with respect to obesity (cg02975187) and two with central obesity (cg12053563, cg12549355) were identified (p < 6 × 10-8). A suggestive association (p < 10-6) was observed at SFRS8 with increasing body mass index. SFRS8 was previously identified with propensity for weight gain in adults.Conclusion
While associations identified with multiple measures related to maternal adiposity suggest different pathways, methylation differences were small in magnitude.
SUBMITTER: Yeung EH
PROVIDER: S-EPMC6371845 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Measured maternal prepregnancy anthropometry and newborn DNA methylation.
Yeung Edwina H EH Guan Weihua W Mumford Sunni L SL Silver Robert M RM Zhang Cuilin C Tsai Michael Y MY Schisterman Enrique F EF
Epigenomics 20190108 2
<h4>Aim</h4>We examined maternal prepregnancy anthropometry and cord blood DNA methylation.<h4>Methods</h4>Associations between maternal measures (i.e., weight, height, waist circumference, hip circumference, skinfolds, leptin) and methylation β-values at each CpG (measured by the Infinium MethylationEPIC BeadChip) were estimated among 391 singletons.<h4>Results</h4>Total of 18% of mothers were obese (body mass index ≥ 30) and 27% centrally obese (waist-to-hip ratio ≥ 0.85). One Bonferroni signi ...[more]
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