Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes.
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ABSTRACT:
SUBMITTER: Ehrlich KC
PROVIDER: S-EPMC6371847 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes.
Ehrlich Kenneth C KC Lacey Michelle M Ehrlich Melanie M
Epigenomics 20190128 2
<h4>Aim</h4>To understand tissue-specific regulation of angiopoietin/angiopoietin-like (ANGPT/ANGPTL) genes (especially the five genes embedded in introns of host genes) and their association with atherosclerosis.<h4>Methods</h4>Transcription and epigenomic databases from various normal tissues were examined in the vicinity of ANGPT1, ANGPT2, ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4 and ANGPTL8.<h4>Results</h4>We identified tissue-specific enhancer chromatin regions that are likely to regulate transcr ...[more]
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