Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes.
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ABSTRACT: Aim
To understand tissue-specific regulation of angiopoietin/angiopoietin-like (ANGPT/ANGPTL) genes (especially the five genes embedded in introns of host genes) and their association with atherosclerosis.Methods
Transcription and epigenomic databases from various normal tissues were examined in the vicinity of ANGPT1, ANGPT2, ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4 and ANGPTL8.Results
We identified tissue-specific enhancer chromatin regions that are likely to regulate transcription of ANGPT/ANGPTL genes and were intragenic, intergenic or host gene-linked. In addition, we found atherosclerosis-linked differentially methylated regions associated with ANGPT2 and with sequences encoding miR-145, a microRNA that targets ANGPT2 mRNA in cancers.Conclusion
Our findings implicate enhancers as major contributors to tissue-specific expression of ANGPT/ANGPTL genes, which play critical roles in angiogenesis, atherosclerosis, cancer, and inflammatory and metabolic diseases.
SUBMITTER: Ehrlich KC
PROVIDER: S-EPMC6371847 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Publications
Tissue-specific epigenetics of atherosclerosis-related ANGPT and ANGPTL genes.
Ehrlich Kenneth C KC Lacey Michelle M Ehrlich Melanie M
Epigenomics 20190128 2
<h4>Aim</h4>To understand tissue-specific regulation of angiopoietin/angiopoietin-like (ANGPT/ANGPTL) genes (especially the five genes embedded in introns of host genes) and their association with atherosclerosis.<h4>Methods</h4>Transcription and epigenomic databases from various normal tissues were examined in the vicinity of ANGPT1, ANGPT2, ANGPTL1, ANGPTL2, ANGPTL3, ANGPTL4 and ANGPTL8.<h4>Results</h4>We identified tissue-specific enhancer chromatin regions that are likely to regulate transcr ...[more]
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