Ontology highlight
ABSTRACT:
SUBMITTER: Ko J
PROVIDER: S-EPMC6372716 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Scientific reports 20190212 1
Transient receptor potential canonical (TRPC) 4 and TRPC5 channels are modulated by the Gα<sub>q</sub>-PLC pathway. Since phosphatidylinositol 4,5-bisphosphate (PI(4,5)P<sub>2</sub>) maintains TRPC4 and TRPC5 channel function, the Gα<sub>q</sub>-PLC pathway inhibits channel activity by depleting PI(4,5)P<sub>2</sub>. Here we investigated the difference in PI(4,5)P<sub>2</sub> sensitivity between homomeric and heteromeric TRPC channels. First, by using a Danio rerio voltage-sensing phosphatase (D ...[more]