Ontology highlight
ABSTRACT:
SUBMITTER: Kelly CJ
PROVIDER: S-EPMC4433427 | biostudies-literature | 2015 May
REPOSITORIES: biostudies-literature
Kelly Caleb J CJ Zheng Leon L Campbell Eric L EL Saeedi Bejan B Scholz Carsten C CC Bayless Amanda J AJ Wilson Kelly E KE Glover Louise E LE Kominsky Douglas J DJ Magnuson Aaron A Weir Tiffany L TL Ehrentraut Stefan F SF Pickel Christina C Kuhn Kristine A KA Lanis Jordi M JM Nguyen Vu V Taylor Cormac T CT Colgan Sean P SP
Cell host & microbe 20150409 5
Interactions between the microbiota and distal gut are fundamental determinants of human health. Such interactions are concentrated at the colonic mucosa and provide energy for the host epithelium through the production of the short-chain fatty acid butyrate. We sought to determine the role of epithelial butyrate metabolism in establishing the austere oxygenation profile of the distal gut. Bacteria-derived butyrate affects epithelial O2 consumption and results in stabilization of hypoxia-inducib ...[more]