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Harms of off-label erythropoiesis-stimulating agents for critically ill people.


ABSTRACT:

SUBMITTER: Mesgarpour B 

PROVIDER: S-EPMC6373621 | biostudies-literature | 2017 Aug

REPOSITORIES: biostudies-literature

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Harms of off-label erythropoiesis-stimulating agents for critically ill people.

Mesgarpour Bita B   Heidinger Benedikt H BH   Roth Dominik D   Schmitz Susanne S   Walsh Cathal D CD   Herkner Harald H  

The Cochrane database of systematic reviews 20170825


<h4>Background</h4>Anaemia is a common problem experienced by critically-ill people. Treatment with erythropoiesis-stimulating agents (ESAs) has been used as a pharmacologic strategy when the blunted response of endogenous erythropoietin has been reported in critically-ill people. The use of ESAs becomes more important where adverse clinical outcomes of transfusing blood products is a limitation. However, this indication for ESAs is not licensed by regulatory authorities and is called off-label  ...[more]

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