Ontology highlight
ABSTRACT:
SUBMITTER: Yan X
PROVIDER: S-EPMC3828003 | biostudies-literature | 2013 Aug
REPOSITORIES: biostudies-literature
CPT: pharmacometrics & systems pharmacology 20130807
Minimal effective concentration (MEC) was proposed to explain why subcutaneous (SC) administration of erythropoietin (EPO) induces a higher hemoglobin (HGB) increase than intravenous (IV) administration. It has been further used to explain the paradox that erythropoiesis-stimulating agent (ESA) with lower receptor binding affinity may have higher in vivo activity. We have developed a pharmacokinetic and pharmacodynamic (PK/PD) model with incorporation of the operational model of agonism to chara ...[more]