Ontology highlight
ABSTRACT:
SUBMITTER: Bisht K
PROVIDER: S-EPMC6373754 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Bisht Kavita K Brunck Marion E ME Matsumoto Taichi T McGirr Crystal C Nowlan Bianca B Fleming Whitney W Keech Thomas T Magor Graham G Perkins Andrew C AC Davies Julie J Walkinshaw Gail G Flippin Lee L Winkler Ingrid G IG Levesque Jean-Pierre JP
Blood advances 20190201 3
In normoxia, hypoxia-inducible transcription factors (HIFs) are rapidly degraded within the cytoplasm as a consequence of their prolyl hydroxylation by oxygen-dependent prolyl hydroxylase domain (PHD) enzymes. We have previously shown that hematopoietic stem and progenitor cells (HSPCs) require HIF-1 for effective mobilization in response to granulocyte colony-stimulating factor (G-CSF) and CXCR4 antagonist AMD3100/plerixafor. Conversely, HIF PHD inhibitors that stabilize HIF-1 protein in vivo e ...[more]