Ontology highlight
ABSTRACT:
SUBMITTER: Wassie AT
PROVIDER: S-EPMC6373868 | biostudies-literature | 2019 Jan
REPOSITORIES: biostudies-literature
Wassie Asmamaw T AT Zhao Yongxin Y Boyden Edward S ES
Nature methods 20181220 1
Many biological investigations require 3D imaging of cells or tissues with nanoscale spatial resolution. We recently discovered that preserved biological specimens can be physically expanded in an isotropic fashion through a chemical process. Expansion microscopy (ExM) allows nanoscale imaging of biological specimens with conventional microscopes, decrowds biomolecules in support of signal amplification and multiplexed readout chemistries, and makes specimens transparent. We review the principle ...[more]