Ontology highlight
ABSTRACT:
SUBMITTER: Nahi H
PROVIDER: S-EPMC6374018 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Nahi Hareth H Chrobok Michael M Gran Charlotte C Lund Johan J Gruber Astrid A Gahrton Gösta G Ljungman Per P Wagner Arnika Kathleen AK Alici Evren E
PloS one 20190213 2
Treatment with Daratumumab (Dara), a monoclonal anti-CD38 antibody of IgG1 subtype, is effective in patients with multiple myeloma (MM). However, Dara also impairs the cellular immunity, which in turn may lead to higher susceptibility to infections. The exact link between immune impairment and infectious complications is unclear. In this study, we report that nine out of 23 patients (39%) with progressive MM had infectious complications after Dara treatment. Five of these patients had viral infe ...[more]