Ontology highlight
ABSTRACT:
SUBMITTER: Feng J
PROVIDER: S-EPMC6374102 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Feng Jiao J Lepetre-Mouelhi Sinda S Gautier Anne A Mura Simona S Cailleau Catherine C Coudore François F Hamon Michel M Couvreur Patrick P
Science advances 20190213 2
The clinical use of endogenous neuropeptides has historically been limited due to pharmacokinetic issues, including plasma stability and blood-brain barrier permeability. In this study, we show that the rapidly metabolized Leu-enkephalin (LENK) neuropeptide may become pharmacologically efficient owing to a simple conjugation with the lipid squalene (SQ). The corresponding LENK-SQ bioconjugates were synthesized using different chemical linkers in order to modulate the LENK release after their for ...[more]