Ontology highlight
ABSTRACT:
SUBMITTER: McClatchy DB
PROVIDER: S-EPMC6374210 | biostudies-literature | 2018 Dec
REPOSITORIES: biostudies-literature
McClatchy Daniel B DB Yu Nam-Kyung NK Martínez-Bartolomé Salvador S Patel Reesha R Pelletier Alexander R AR Lavalle-Adam Mathieu M Powell Susan B SB Roberto Marisa M Yates John R JR
ACS chemical neuroscience 20180813 12
Kinases are a major clinical target for human diseases. Identifying the proteins that interact with kinases in vivo will provide information on unreported substrates and will potentially lead to more specific methods for therapeutic kinase regulation. Here, endogenous immunoprecipitations of evolutionally distinct kinases (i.e., Akt, ERK2, and CAMK2) from rodent hippocampi were analyzed by mass spectrometry to generate three highly confident kinase protein-protein interaction networks. Proteins ...[more]