Ontology highlight
ABSTRACT:
SUBMITTER: Lopez-Perez O
PROVIDER: S-EPMC6374525 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
López-Pérez Óscar Ó Otero Alicia A Filali Hicham H Sanz-Rubio David D Toivonen Janne M JM Zaragoza Pilar P Badiola Juan J JJ Bolea Rosa R Martín-Burriel Inmaculada I
Scientific reports 20190213 1
Autophagy is a dynamic cellular mechanism involved in protein and organelle turnover through lysosomal degradation. Autophagy regulation modulates the pathologies associated with many neurodegenerative diseases. Using sheep naturally infected with scrapie as a natural animal model of prion diseases, we investigated the regulation of autophagy in the central nervous system (CNS) during the clinical phase of the disease. We present a gene expression and protein distribution analysis of different a ...[more]