Ontology highlight
ABSTRACT:
SUBMITTER: Sonavane M
PROVIDER: S-EPMC6374779 | biostudies-literature | 2018 Jun
REPOSITORIES: biostudies-literature
Sonavane Manoj M Sykora Peter P Andrews Joel F JF Sobol Robert W RW Gassman Natalie R NR
Chemical research in toxicology 20180605 6
Bisphenol A (BPA) is used heavily in the production of polycarbonate plastics, thermal receipt paper, and epoxies. Ubiquitous exposure to BPA has been linked to obesity, diabetes, and breast and reproductive system cancers. Resistance to chemotherapeutic agents has also been shown in cancer cell models. Here, we investigated BPA's ability to confer resistance to camptothecin (CPT) in mouse embryonic fibroblasts (MEFs). MEFs are sensitive to CPT; however, co-exposure of BPA with CPT improved cell ...[more]