Ontology highlight
ABSTRACT:
SUBMITTER: Hamano M
PROVIDER: S-EPMC4865675 | biostudies-literature | 2016 Jun
REPOSITORIES: biostudies-literature
Hamano Momoko M Sayano Tomoko T Kusada Wataru W Kato Hisanori H Furuya Shigeki S
Data in brief 20160426
Inherent ʟ-Ser deficiency culminates in intrauterine growth retardation, severe malformation of multiple organs particularly the central nervous system, and perinatal or early postnatal death in human and mouse. To uncover the molecular mechanisms underlying the growth-arrested phenotypes of l-Ser deficiency, we compared gene expression profiles of mouse embryonic fibroblasts deficient in 3-phosphoglycerate dehydrogenase (Phgdh), the first enzyme of de novo ʟ-Ser synthetic pathway, between ʟ-Ser ...[more]