Ontology highlight
ABSTRACT:
SUBMITTER: Karyakarte SD
PROVIDER: S-EPMC6375082 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Angewandte Chemie (International ed. in English) 20180903 39
Spirocyclic ethers can be found in bioactive compounds. This copper-catalyzed enantioselective alkene carboetherification provides 5,5-, 5,6- and 6,6-spirocyclic products containing fully substituted chiral carbon centers with up to 99 % enantiomeric excess. This reaction features the formation of two rings from acyclic substrates, 1,1-disubstituted alkenols functionalized with either arenes, alkenes, or alkynes, and clearly constitutes a powerful way to synthesize chiral spirocyclic ethers. ...[more]