Ontology highlight
ABSTRACT:
SUBMITTER: Miller Y
PROVIDER: S-EPMC3430129 | biostudies-literature | 2012 Jul
REPOSITORIES: biostudies-literature
Journal of the American Chemical Society 20120705 29
Fused-ring and bridged-ring tetrahydrofuran scaffolds are found in a number of natural products and biologically active compounds. A new copper-catalyzed intramolecular carboetherification of alkenes for the synthesis of bicyclic tetrahydrofurans is reported herein. The reaction involves Cu-catalyzed intramolecular addition of alcohols to unactivated alkenes and subsequent aryl C-H functionalization provides the C-C bond. Mechanistic studies indicate a primary carbon radical intermediate is invo ...[more]