Ontology highlight
ABSTRACT:
SUBMITTER: Piasecka A
PROVIDER: S-EPMC6376114 | biostudies-literature | 2018 Mar
REPOSITORIES: biostudies-literature
Piasecka Anna A Czapinska Honorata H Vielberg Marie-Theres MT Szczepanowski Roman H RH Kiefersauer Reiner R Reed Simon S Groll Michael M Bochtler Matthias M
Journal of molecular biology 20171216 5
Ancestral β-subunit (Anbu) is homologous to HslV and 20S proteasomes. Based on its phylogenetic distribution and sequence clustering, Anbu has been proposed as the "ancestral" form of proteasomes. Here, we report biochemical data, small-angle X-ray scattering results, negative-stain electron microscopy micrographs and a crystal structure of the Anbu particle from Yersinia bercovieri (YbAnbu). All data are consistent with YbAnbu forming defined 12-14 subunit multimers that differ in shape from bo ...[more]