Ontology highlight
ABSTRACT:
SUBMITTER: Lazzaretti D
PROVIDER: S-EPMC6238398 | biostudies-literature | 2018 Oct
REPOSITORIES: biostudies-literature
Lazzaretti Daniela D Bandholz-Cajamarca Lina L Emmerich Christiane C Schaaf Kristina K Basquin Claire C Irion Uwe U Bono Fulvia F
Life science alliance 20181018 5
During mRNA localization, RNA-binding proteins interact with specific structured mRNA localization motifs. Although several such motifs have been identified, we have limited structural information on how these interact with RNA-binding proteins. Staufen proteins bind structured mRNA motifs through dsRNA-binding domains (dsRBD) and are involved in mRNA localization in <i>Drosophila</i> and mammals. We solved the structure of two dsRBDs of human Staufen1 in complex with a physiological dsRNA seque ...[more]