Ontology highlight
ABSTRACT:
SUBMITTER: Qian M
PROVIDER: S-EPMC6376278 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Qian Maoxiang M Xu Heng H Perez-Andreu Virginia V Roberts Kathryn G KG Zhang Hui H Yang Wenjian W Zhang Shouyue S Zhao Xujie X Smith Colton C Devidas Meenakshi M Gastier-Foster Julie M JM Raetz Elizabeth E Larsen Eric E Burchard Esteban G EG Winick Naomi N Bowman W Paul WP Martin Paul L PL Borowitz Michael M Wood Brent B Antillon-Klussmann Federico F Pui Ching-Hon CH Mullighan Charles G CG Evans William E WE Hunger Stephen P SP Relling Mary V MV Loh Mignon L ML Yang Jun J JJ
Blood 20181203 7
Acute lymphoblastic leukemia (ALL) is the most common malignancy in children. Characterized by high levels of Native American ancestry, Hispanics are disproportionally affected by this cancer with high incidence and inferior survival. However, the genetic basis for this disparity remains poorly understood because of a paucity of genome-wide investigation of ALL in Hispanics. Performing a genome-wide association study (GWAS) in 940 Hispanic children with ALL and 681 ancestry-matched non-ALL contr ...[more]