Ontology highlight
ABSTRACT:
SUBMITTER: Becker JC
PROVIDER: S-EPMC6376503 | biostudies-literature | 2019 Jan-Dec
REPOSITORIES: biostudies-literature
Becker Jennifer C JC Tollefson Sharon J SJ Weaver David D Williams John V JV
Antiviral chemistry & chemotherapy 20190101
Human metapneumovirus, a paramyxovirus discovered in 2001, is a major cause of lower respiratory infection in adults and children worldwide. There are no licensed vaccines or drugs for human metapneumovirus. We developed a fluorescent, cell-based medium-throughput screening assay for human metapneumovirus that captures inhibitors of all stages of the viral lifecycle except budding of progeny virus particles from the cell membrane. We optimized and validated the assay and performed a successful m ...[more]