Dataset Information

Clinical outcome of Escherichia coli bloodstream infection in cancer patients with/without biofilm formation: a single-center retrospective study.

ABSTRACT:

Background

Extended-spectrum ?-lactamase-producing Escherichia coli (ESBL-EC) is one of the main antimicrobial-resistant pathogens. Little data are available on how biofilm formation (BF) contributes to EC-caused bloodstream infection (BSI) in cancer patients. This study investigated the impact of BF on clinical outcomes of cancer patients with EC-caused BSI.

Methods

Clinical outcome and microbiological characteristics including the presence of bla genes in ESBL-EC isolates were retrospectively collected from BSI cancer patients. Patients infected with ESBL-EC were compared with patients infected with third-generation cephalosporin-susceptible strains. Survival curves were generated by Kaplan-Meier analysis and the survival difference was assessed by the log-rank test. Risk factors for ESBL-EC infection, predictors of mortality, and outcome differences were determined by multivariate logistic regression and Cox regression analysis, respectively.

Results

A high prevalence of ESBL-EC with dominant bla _CTX-M-15, bla _CTX-M-15 plus bla _TEM-52 genotype was found in BSI cancer patients. Independent risk factors for infection with ESBL-EC were cephalosporins, chemotherapy, and BF. Metastasis, ICU admission, BF-positive ESBL-EC, organ failure, and the presence of septic shock were revealed as predictors for mortality. The ESBL characteristic was associated with the BF phenotype, and the overall mortality was significantly higher in cancer patients with BF-positive ESBL-EC-caused BSI.

Conclusion

bla _CTX-M-15 type ESBL-EC is highly endemic among cancer patients with BSI. BF is associated with multi-drug resistance by ESBL-EC and is also an independent risk factor of mortality for cancer patients with BSI. Our findings suggest that the combination of BF-positive ESBL-EC isolates with other appropriate laboratory indicators might benefit infection control and improve clinical outcomes.

SUBMITTER: Zhang Q

PROVIDER: S-EPMC6377049 | biostudies-literature | 2019

REPOSITORIES: biostudies-literature

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Publications

Clinical outcome of <i>Escherichia coli</i> bloodstream infection in cancer patients with/without biofilm formation: a single-center retrospective study.

Zhang Qing Q Gao Hao-Yang HY Li Ding D Li Zheng Z Qi Shan-Shan SS Zheng Shan S Bai Chang-Sen CS Zhang Si-He SH

Infection and drug resistance 20190211

<h4>Background</h4>Extended-spectrum β-lactamase-producing <i>Escherichia coli</i> (ESBL-EC) is one of the main antimicrobial-resistant pathogens. Little data are available on how biofilm formation (BF) contributes to EC-caused bloodstream infection (BSI) in cancer patients. This study investigated the impact of BF on clinical outcomes of cancer patients with EC-caused BSI.<h4>Methods</h4>Clinical outcome and microbiological characteristics including the presence of <i>bla</i> genes in ESBL-EC i ...[more]

PMID: 30809097

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