Ontology highlight
ABSTRACT:
SUBMITTER: Gurevich VV
PROVIDER: S-EPMC6377262 | biostudies-literature | 2019 Mar
REPOSITORIES: biostudies-literature
Gurevich Vsevolod V VV Gurevich Eugenia V EV
Molecular and cellular endocrinology 20190128
G protein-coupled receptors (GPCRs) are the largest family of signaling proteins targeted by more clinically used drugs than any other protein family. GPCR signaling via G proteins is quenched (desensitized) by the phosphorylation of the active receptor by specific GPCR kinases (GRKs) followed by tight binding of arrestins to active phosphorylated receptors. Thus, arrestins engage two types of receptor elements: those that contain GRK-added phosphates and those that change conformation upon acti ...[more]