Ontology highlight
ABSTRACT:
SUBMITTER: Wang J
PROVIDER: S-EPMC6377289 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Wang Jiaqing J Zhou Jie J He Hongjian H Wu Difei D Du Xuewen X Xu Bing B
Chembiochem : a European journal of chemical biology 20181210 4
Phosphatases play an important role in cell biology, but only a few probes are suitable for selectively imaging phosphatase activity in live cells, because the current probes require cell fixation or exhibit considerable cytotoxicity. Herein, we show that conjugating a d-peptide to a quinazolinone derivative generates cell-compatible, biostable probes for imaging the phosphatase activity inside live cells. Moreover, our results show that inhibiting ectophosphatases is a critical factor for imagi ...[more]