Ontology highlight
ABSTRACT:
SUBMITTER: Koma H
PROVIDER: S-EPMC6377412 | biostudies-literature | 2019 Jul
REPOSITORIES: biostudies-literature
Koma Hiromi H Yamamoto Yasuhiro Y Fujita Tomonari T Yagami Tatsurou T
Biochemistry and biophysics reports 20190214
Renal cell carcinoma (RCC) is relatively resistant to chemotherapy and radiotherapy. Clear cell RCC (ccRCC) accounts for the majority of RCC, which have mutations or epigenetic silencing of the <i>von Hippel-Lindau</i> (<i>VHL</i>) gene. VHL-positive Caki-2 cells are killed by an endogenous anticancer substance, 15-deoxy-Δ<sup>12, 14</sup>-prostaglandin J<sub>2</sub> (15d-PGJ<sub>2</sub>). The MTT reduction assay reflecting mitochondrial succinate dehydrogenase activity was employed for assessme ...[more]