Ontology highlight
ABSTRACT:
SUBMITTER: Liu Y
PROVIDER: S-EPMC6377630 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Communications biology 20190215
Hostile environmental cues cause <i>Mycobacterium tuberculosis</i> to enter a state of slow growth for survival. However, the underlying regulatory mechanism remains unclear. DnaA is essential for DNA replication initiation and represents an efficient target for growth regulation in bacteria. Here, we show that the nucleoid-associated protein NapM is a DnaA antagonist, protecting <i>M. tuberculosis</i> from stress-mediated killing. NapM can be induced by diverse stressful signals. It binds to Dn ...[more]