Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer.
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ABSTRACT:
SUBMITTER: Wang A
PROVIDER: S-EPMC6377662 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
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Long noncoding RNA EGFR-AS1 promotes cell growth and metastasis via affecting HuR mediated mRNA stability of EGFR in renal cancer.
Wang Anbang A Bao Yi Y Wu Zhenjie Z Zhao Tangliang T Wang Dong D Shi Jiazi J Liu Bing B Sun Shuhan S Yang Fu F Wang Linhui L Qu Le L
Cell death & disease 20190215 3
Long noncoding RNAs (lncRNAs) are implicated in renal cell carcinoma (RCC), but remain largely unclear. Using publicly available transcriptome sequencing data from renal cancer (n = 703) and integrating bioinformatics analyses, we screened and identified a valuable lncRNA, EGFR-AS1. In our validation cohort (n = 204), EGFR-AS1 was significantly upregulated in RCC tissues (P < 0.001). Gain-of-function and loss-of-function studies showed that EGFR-AS1 promoted cell proliferation and invasion in vi ...[more]
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