Ontology highlight
ABSTRACT:
SUBMITTER: Adachi N
PROVIDER: S-EPMC6378987 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
The Journal of biological chemistry 20181212 7
With few reported exceptions, G protein-coupled receptors (GPCRs) are modified by Cys palmitoylation (<i>S</i>-palmitoylation). In multiple GPCRs, <i>S</i>-palmitoylation targets a canonical site within the C-terminal cytoplasmic tail adjacent to the C terminus of the seventh transmembrane domain, but modification of additional sites is exemplified by the β-adrenergic receptors (βARs). The β<sub>1</sub>AR is <i>S</i>-palmitoylated at a second, more distal site within the C-terminal tail, and the ...[more]