Ontology highlight
ABSTRACT:
SUBMITTER: Malod-Dognin N
PROVIDER: S-EPMC6379402 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Malod-Dognin Noël N Petschnigg Julia J Windels Sam F L SFL Povh Janez J Hemingway Harry H Ketteler Robin R Pržulj Nataša N
Nature communications 20190218 1
We are increasingly accumulating molecular data about a cell. The challenge is how to integrate them within a unified conceptual and computational framework enabling new discoveries. Hence, we propose a novel, data-driven concept of an integrated cell, iCell. Also, we introduce a computational prototype of an iCell, which integrates three omics, tissue-specific molecular interaction network types. We construct iCells of four cancers and the corresponding tissue controls and identify the most rew ...[more]