Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.
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ABSTRACT:
SUBMITTER: Cheng Y
PROVIDER: S-EPMC6915746 | biostudies-literature | 2019
REPOSITORIES: biostudies-literature
Publications
Targeting epigenetic regulators for cancer therapy: mechanisms and advances in clinical trials.
Cheng Yuan Y He Cai C Wang Manni M Ma Xuelei X Mo Fei F Yang Shengyong S Han Junhong J Wei Xiawei X
Signal transduction and targeted therapy 20191217
Epigenetic alternations concern heritable yet reversible changes in histone or DNA modifications that regulate gene activity beyond the underlying sequence. Epigenetic dysregulation is often linked to human disease, notably cancer. With the development of various drugs targeting epigenetic regulators, epigenetic-targeted therapy has been applied in the treatment of hematological malignancies and has exhibited viable therapeutic potential for solid tumors in preclinical and clinical trials. In th ...[more]
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