Ontology highlight
ABSTRACT:
SUBMITTER: Morishita A
PROVIDER: S-EPMC6380525 | biostudies-literature | 2018
REPOSITORIES: biostudies-literature
Morishita A A Gerber A A Gow C-H CH Zelonina T T Chada K K D'Armiento J J
Journal of cancer research forecast 20181105 2
MMP1, a matrix metalloproteinase that degrades the extracellular matrix, is produced not only by cancer cells but also synthesized in stromal and inflammatory cells during tumorigenesis, invasion and lung metastasis. However, the function of MMP1 expression from host cells, especially tumor-associated macrophages (TAMs), and cells in the lung parenchyma remains to be elucidated. Here we demonstrate that <i>in vitro</i> macrophages co-cultured with tumor cells drastically enhance MMP1 expression, ...[more]