Ontology highlight
ABSTRACT:
SUBMITTER: Guo L
PROVIDER: S-EPMC6381112 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Guo Ling L Cui Chunhong C Zhang Kuo K Wang Jiaxin J Wang Yilin Y Lu Yixuan Y Chen Ka K Yuan Jifan J Xiao Guozhi G Tang Bin B Sun Ying Y Wu Chuanyue C
Nature communications 20190219 1
Cell metabolism is strongly influenced by mechano-environment. We show here that a fraction of kindlin-2 localizes to mitochondria and interacts with pyrroline-5-carboxylate reductase 1 (PYCR1), a key enzyme for proline synthesis. Extracellular matrix (ECM) stiffening promotes kindlin-2 translocation into mitochondria and its interaction with PYCR1, resulting in elevation of PYCR1 level and consequent increase of proline synthesis and cell proliferation. Depletion of kindlin-2 reduces PYCR1 leve ...[more]