Ontology highlight
ABSTRACT:
SUBMITTER: Hou Z
PROVIDER: S-EPMC6382003 | biostudies-literature | 2019 Feb
REPOSITORIES: biostudies-literature
Hou Zhili Z Wu Qi Q Sun Xin X Chen Huaiyong H Li Yu Y Zhang Yongchun Y Mori Munemasa M Yang Ying Y Que Jianwen J Jiang Ming M
Development (Cambridge, England) 20190211 3
Basal progenitor cells are crucial for the establishment and maintenance of the tracheal epithelium. However, it remains unclear how these progenitor cells are specified during foregut development. Here, we found that ablation of the Wnt chaperone protein Gpr177 (also known as Wntless) in mouse tracheal epithelium causes a significant reduction in the number of basal progenitor cells accompanied by cartilage loss in <i>Shh-Cre;Gpr177<sup>loxp/loxp</sup></i> mutants. Consistent with the associati ...[more]