Ontology highlight
ABSTRACT:
SUBMITTER: Smith BA
PROVIDER: S-EPMC6382070 | biostudies-literature | 2018 Sep
REPOSITORIES: biostudies-literature
Smith Bryan A BA Balanis Nikolas G NG Nanjundiah Avinash A Sheu Katherine M KM Tsai Brandon L BL Zhang Qingfu Q Park Jung Wook JW Thompson Michael M Huang Jiaoti J Witte Owen N ON Graeber Thomas G TG
Cell reports 20180901 12
Cancer progression to an aggressive phenotype often co-opts aspects of stem cell biology. Here, we developed gene signatures for normal human stem cell populations to understand the relationship between epithelial cancers and stem cell transcriptional programs. Using a pan-cancer approach, we reveal that aggressive epithelial cancers are enriched for a transcriptional signature shared by epithelial adult stem cells. The adult stem cell signature selected for epithelial cancers with worse overall ...[more]